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KMID : 1137020120230040288
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Journal of Gynecologic Oncology
2012 Volume.23 No. 4 p.288 ~ p.290
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Sweet’s syndrome: a cutaneous harbinger of ovarian carcinoma
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Fader Amanda Nickles
Winder Abigail Duncan
Sandadi Samith
DeBernardo Robert
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Abstract
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Sweet’s syndrome, or acute febrile neutrophilic dermatosis, is a condition characterized by fever, neutrophilia, erythematous skin lesions, and a dermal infiltrate consisting predominantly of mature neutrophils on histology. Sweet’s syndrome is a reactive phenomenon and should be considered a cutaneous marker of systemic disease, including underlying malignancy. We present a case of a 56-year-old woman who presented with vague abdominal symptoms and a tender, erythematous rash on her extremities. Biopsy of her skin lesions revealed Sweet’s syndrome. A work-up for malignancy eventually demonstrated a pelvic mass and carcinomatosis, and a diagnosis of advanced-stage papillary serous ovarian carcinoma was subsequently made. In postmenopausal women who present with Sweet’s syndrome, a comprehensive evaluation for malignancy is indicated. In women with a known diagnosis of cancer, Sweet’s syndrome may manifest in the detection of persistent or recurrent disease.
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KEYWORD
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Cutaneous rash, Neutrophilia, Ovarian neoplasms, Paraneoplastic syndrome, Sweet’s syndrome
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